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CRIS-Plugin Publikationen LS2
2019
Cantone M. , Küspert M. , Reiprich S. , Lai X. , Eberhardt M. , Göttle P. , Beyer F. , Azim K. , Küry P. , Wegner M. , Vera J. :A gene regulatory architecture that controls region-independent dynamics of oligodendrocyte differentiation Glia 2019 )ISSN: 0894-1491 10.1002/glia.23569 Elsesser O. , Fröb F. , Küspert M. , Tamm ER. , Fujii T. , Fukunaga R. , Wegner M. :Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system Nucleic Acids Research 47 2019 ), S. 6208-6224 ISSN: 0305-1048 10.1093/nar/gkz376 Fröb F. , Sock E. , Tamm ER. , Saur AL. , Hillgärtner S. , Williams TJ. , Fujii T. , Fukunaga R. , Wegner M. :Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy Nature Communications 10 2019 )ISSN: 2041-1723 10.1038/s41467-019-10287-w Fröb F. , Wegner M. :The role of chromatin remodeling complexes in Schwann cell development Glia 2019 )ISSN: 0894-1491 10.1002/glia.23766 Sock E. , Wegner M. :Transcriptional control of myelination and remyelination Glia 2019 )ISSN: 0894-1491 10.1002/glia.23636 Vogel J. , Weider M. , Engler L. , Hillgärtner S. , Schmitt C. , Hermans-Borgmeyer I. , Wegner M. :Sox9 overexpression exerts multiple stage-dependent effects on mouse spinal cord development Glia 2019 )ISSN: 0894-1491 10.1002/glia.23752
Alle öffnen
2018
Hoffmann A. , Ettle B. , Battis K. , Reiprich S. , Schlachetzki J. , Masliah E. , Wegner M. , Kuhlmann T. , Riemenschneider MJ. , Winkler J. :Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy Brain Pathology 2018 )ISSN: 1015-6305 10.1111/bpa.12678 Jacob A. , Wüst H. , Thalhammer J. , Fröb F. , Küspert M. , Reiprich S. , Balta EA. , Lie DC. , Wegner M. , Sock E. :The transcription factor prospero homeobox protein 1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis Journal of Neurochemistry 146 2018 ), S. 251-268 ISSN: 0022-3042 10.1111/jnc.14456 Kozlenkov A. , Li J. , Apontes P. , Hurd YL. , Byne WM. , Koonin E. , Wegner M. , Mukamel EA. , Dracheva S. :A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons Science Advances 4 2018 )ISSN: 2375-2548 10.1126/sciadv.aau6190 Menzel-Severing J. , Zenkel M. , Polisetti N. , Sock E. , Wegner M. , Kruse F. , Schlötzer-Schrehardt U. :Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/progenitor cells Scientific Reports 8 2018 )ISSN: 2045-2322 10.1038/s41598-018-28596-3 Neirijnck Y. , Reginensi A. , Renkema KY. , Massa F. , Kozlov VM. , Dhib H. , Bongers EMHF. , Feitz WF. , Van Eerde AM. , Lefebvre V. , Knoers NVAM. , Tabatabaei M. , Schulz H. , Mcneill H. , Schaefer F. , Wegner M. , Sock E. , Schedl A. :Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT). Kidney International 93 2018 ), S. 1142-1153 ISSN: 0085-2538 10.1016/j.kint.2017.11.026 Parfejevs V. , Debbache J. , Shakhova O. , Schaefer SM. , Glausch M. , Wegner M. , Suter U. , Riekstina U. , Werner S. , Sommer L. :Injury-activated glial cells promote wound healing of the adult skin in mice. Nature Communications 9 2018 ), S. 236 ISSN: 2041-1723 10.1038/s41467-017-01488-2 Prochnicki A. , Amann KU. , Wegner M. , Sock E. , Pfister E. , Shankland S. , Pippin J. , Daniel C. :Characterization of Glomerular Sox9+ Cells in Anti-Glomerular Basement Membrane Nephritis in the Rat American Journal of Pathology 188 2018 ), S. 2529-2541 ISSN: 0002-9440 10.1016/j.ajpath.2018.07.023 Rich CA. , Perera SN. , Andratschke J. , Stolt C. , Buehler DP. , Southard-Smith EM. , Wegner M. , Britsch S. , Baker CVH. :Olfactory ensheathing cells abutting the embryonic olfactory bulb express Frzb, whose deletion disrupts olfactory axon targeting Glia 66 2018 ), S. 2617-2631 ISSN: 0894-1491 10.1002/glia.23515 Truch K. , Arter J. , Turnescu T. , Weider M. , Hartwig A. , Tamm ER. , Sock E. , Wegner M. :Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease. Human Molecular Genetics 27 2018 ), S. 1078-1092 ISSN: 0964-6906 10.1093/hmg/ddy029 Turnescu T. , Arter J. , Reiprich S. , Tamm ER. , Reiprich S. , Waisman A. , Wegner M. :Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes. Glia 66 2018 ), S. 279-294 ISSN: 0894-1491 10.1002/glia.23242 Weider M. , Starost LJ. , Groll K. , Küspert M. , Sock E. , Wedel M. , Fröb F. , Schmitt C. , Baroti T. , Hartwig A. , Hillgärtner S. , Piefke S. , Fadler T. , Ehrlich M. , Ehlert C. , Stehling M. , Albrecht S. , Jabali A. , Schoeler HR. , Winkler J. , Kuhlmann T. , Wegner M. :Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nature Communications 9 2018 ), S. 899 ISSN: 2041-1723 10.1038/s41467-018-03336-3 Weider M. , Starost LJ. , Groll K. , Küspert M. , Sock E. , Wedel M. , Fröb F. , Schmitt C. , Baroti T. , Hartwig A. , Hillgärtner S. , Piefke S. , Fadler T. , Ehrlich M. , Ehlert C. , Stehling M. , Albrecht S. , Jabali A. , Schoeler HR. , Winkler J. , Kuhlmann T. , Wegner M. :Publisher Correction: Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning Nature Communications 9 2018 )ISSN: 2041-1723 10.1038/s41467-018-03871-z Wüst H. , Wegner M. :Oncogenic insult to the brain: Sox proteins rise to the occasion. TRANSLATIONAL CANCER RESEARCH 7 2018 ), S. S31-S33 ISSN: 2218-676X 10.21037/tcr.2017.12.19
2017
Duncan GJ. , Plemel JR. , Assinck P. , Manesh SB. , Muir FGW. , Hirata R. , Berson M. , Liu J. , Wegner M. , Emery B. , Moore GRW. , Tetzlaff W. :Myelin Regulatory Factor 1 Drives Remyelination in Multiple Sclerosis. Acta Neuropathologica 2017 ), S. 403-422 ISSN: 0001-6322 10.1007/s00401-017-1741-7 Marathe HG. , Watkins-Chow DE. , Weider M. , Hoffmann A. , Trivedi A. , Aras S. , Mehta G. , Basuroy T. , Mehrotra A. , Bennett DC. , Wegner M. , Pavan WJ. , De La Serna IL. :BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation. Nucleic Acids Research 45 2017 ), S. 6442-6458 ISSN: 0305-1048 10.1093/nar/gkx259 Mehta P. , Küspert M. , Bale T. , Brownstein CA. , Towne MC. , De Girolami U. , Shi J. , Beggs AH. , Darras BT. , Wegner M. , Piao X. , Agrawal PB. :Novel mutation in CNTNAP1 results in congenital hypomyelinating neuropathy. Muscle & Nerve 2017 ), S. 761-765 ISSN: 0148-639X 10.1002/mus.25416 Reiprich S. , Cantone M. , Weider M. , Baroti T. , Wittstatt J. , Schmitt C. , Küspert M. , Vera J. , Wegner M. :Transcription factor Sox10 regulates oligodendroglial Sox9 levels via microRNAs. Glia 65 2017 ), S. 1089-1102 ISSN: 0894-1491 10.1002/glia.23146 Wegener A. , Küspert M. , Sock E. , Philipsen S. , Suske G. , Wegner M. :Sp2 is the only glutamine-rich Specificity protein with minor impact on development and differentiation in myelinating glia. Journal of Neurochemistry 140 2017 ), S. 245-256 ISSN: 0022-3042 10.1111/jnc.13908 Weider M. , Wegner M. :SoxE factors: Transcriptional regulators of neural differentiation and nervous system development. Seminars in Cell & Developmental Biology 2017 ), S. 35-42. ISSN: 1084-9521 10.1016/j.semcdb.2016.08.013
2016
Baroti T. , Schillinger A. , Wegner M. , Stolt C. :Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes Journal of Neurochemistry 136 2016 ), S. 316-28 ISSN: 0022-3042 10.1111/jnc.13414 Baroti T. , Zimmermann Y. , Schillinger A. , Liu L. , Lommes P. , Wegner M. , Stolt C. :Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain Glia 64 2016 ), S. 122-38 ISSN: 0894-1491 10.1002/glia.22919 Ettle B. , Kerman BE. , Valera E. , Gillmann C. , Schlachetzki J. , Reiprich S. , Büttner C. , Ekici AB. , Reis A. , Wegner M. , Bäuerle T. , Riemenschneider MJ. , Masliah E. , Gage FH. , Winkler J. :?-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy Acta Neuropathologica 132 2016 ), S. 59-75 ISSN: 0001-6322 10.1007/s00401-016-1572-y Kozlenkov A. , Wang M. , Roussos P. , Rudchenko S. , Barbu M. , Bibikova M. , Klotzle B. , Dwork AJ. , Zhang B. , Hurd YL. , Koonin EV. , Wegner M. , Dracheva S. :Substantial DNA methylation differences between two major neuronal subtypes in human brain Nucleic Acids Research 44 2016 ), S. 2593-612 ISSN: 0305-1048 10.1093/nar/gkv1304 Küspert M. , Wegner M. :SomethiNG 2 talk about-Transcriptional regulation in embryonic and adult oligodendrocyte precursors Brain Research 1638 2016 ), S. 167-82 ISSN: 0006-8993 10.1016/j.brainres.2015.07.024 Muth K. , Piefke S. , Weider M. , Sock E. , Hermans-Borgmeyer I. , Wegner M. , Küspert M. :The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes Glia 64 2016 ), S. 2120-2132 ISSN: 0894-1491 10.1002/glia.23044 Quintes S. , Brinkmann BG. , Ebert M. , Fröb F. , Kungl T. , Arlt FA. , Tarabykin V. , Huylebroeck D. , Meijer D. , Suter U. , Wegner M. , Sereda MW. , Nave KA. :Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair Nature Neuroscience 19 2016 ), S. 1050-9 ISSN: 1097-6256 10.1038/nn.4321 Stolt C. , Wegner M. :Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination Brain Research 1641 2016 ), S. 101-10 ISSN: 0006-8993 10.1016/j.brainres.2015.09.025 Moyon S., Huynh J.L, Dutta D., Zhang F., Ma D., Yoo S., Lawrence R., Wegner Michael, John G.R., Emery B., Lubetzki C., Franklin R.J.M., Fan G., Zhu J., Dupree J.L, Casaccia P.:Functional characterization of DNA methylation in the oligodendrocyte lineage. Cell Reports 2016 ), S. 748-760 ISSN: 2211-1247 10.1016/j.celrep.2016.03.060
2015
Amaya DA. , Wegner M. , Stolt C. , Chehrehasa F. , Ekberg JAK. , St John JA. :Radial glia phagocytose axonal debris from degenerating overextending axons in the developing olfactory bulb Journal of Comparative Neurology 523 2015 ), S. 183-96 ISSN: 0021-9967 10.1002/cne.23665 Anderson SR. , Lee I. , Ebeling C. , Stephenson DA. , Schweitzer KM. , Baxter D. , Moon TM. , Lapierre S. , Jaques B. , Silvius D. , Wegner M. , Hood LE. , Carlson G. , Gunn TM. :Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice Mammalian Genome 26 2015 ), S. 80-93 ISSN: 0938-8990 10.1007/s00335-014-9548-5 Arter J. , Wegner M. :Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells Journal of Neurochemistry 132 2015 ), S. 384-93 ISSN: 0022-3042 10.1111/jnc.13013 Bischof M. , Weider M. , Küspert M. , Nave KA. , Wegner M. :Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation The Journal of Neuroscience 35 2015 ), S. 21-35 ISSN: 1529-2401 10.1523/JNEUROSCI.1468-14.2015 Kim GJ. , Sock E. , Buchberger A. , Just W. , Denzer F. , Hoepffner W. , German J. , Cole T. , Mann J. , Seguin JH. , Zipf W. , Costigan C. , Schmiady H. , Rostasy M. , Kramer M. , Kaltenbach S. , Roesler B. , Georg I. , Troppmann E. , Teichmann AC. , Salfelder A. , Widholz SA. , Wieacker P. , Hiort O. , Camerino G. , Radi O. , Wegner M. , Arnold HH. , Scherer G. :Copy number variation of two separate regulatory regions upstream of SOX9 causes isolated 46,XY or 46,XX disorder of sex development Journal of Medical Genetics 52 2015 ), S. 240-7 ISSN: 0022-2593 10.1136/jmedgenet-2014-102864 Lang H. , Xing Y. , Brown LN. , Samuvel DJ. , Panganiban CH. , Havens LT. , Balasubramanian S. , Wegner M. , Krug EL. , Barth JL. :Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve Scientific Reports 5 2015 ), S. 13383 ISSN: 2045-2322 10.1038/srep13383 Quiroga AC. , Stolt C. , Diez Del Corral R. , Dimitrov S. , Perez-Alcala S. , Sock E. , Barbas JA. , Wegner M. , Morales AV. :Sox5 controls dorsal progenitor and interneuron specification in the spinal cord Developmental Neurobiology 75 2015 ), S. 522-38 ISSN: 1932-8451 10.1002/dneu.22240 Reiprich S. , Wegner M. :From CNS stem cells to neurons and glia: Sox for everyone Cell and Tissue Research 359 2015 ), S. 111-24 ISSN: 0302-766X 10.1007/s00441-014-1909-6 Shakhova O. , Cheng P. , Mishra PJ. , Zingg D. , Schaefer SM. , Debbache J. , Haeusel J. , Matter C. , Guo T. , Davis S. , Meltzer P. , Mihic-Probst D. , Moch H. , Wegner M. , Merlino G. , Levesque MP. , Dummer R. , Santoro R. , Cinelli P. , Sommer L. :Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma PLoS Genetics 11 2015 ), S. e1004877 ISSN: 1553-7390 10.1371/journal.pgen.1004877 Wegener A. , Deboux C. , Bachelin C. , Frah M. , Kerninon C. , Seilhean D. , Weider M. , Wegner M. , Nait-Oumesmar B. :Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination Brain 138 2015 ), S. 120-35 ISSN: 0006-8950 10.1093/brain/awu375 Weider M. , Wegener A. , Schmitt-Engel C. , Küspert M. , Hillgaertner S. , Boesl MR. , Hermans-Borgmeyer I. , Nait-Oumesmar B. , Wegner M. :Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells PLoS Genetics 11 2015 ), S. e1005008 ISSN: 1553-7390 10.1371/journal.pgen.1005008
2014
Ettle B. , Reiprich S. , Deußer J. , Schlachetzki J. , Xiang W. , Prots I. , Masliah E. , Winner B. , Wegner M. , Winkler J. :Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells Molecular and Cellular Neuroscience 62 2014 ), S. 68-78 ISSN: 1044-7431 10.1016/j.mcn.2014.06.012 Glasgow SM. , Zhu W. , Stolt C. , Huang TW. , Chen F. , Loturco JJ. , Neul JL. , Wegner M. , Mohila C. , Deneen B. :Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes Nature Neuroscience 17 2014 ), S. 1322-9 ISSN: 1097-6256 10.1038/nn.3790 Hoffmann SA. , Hos D. , Küspert M. , Lang RA. , Lovell-Badge R. , Wegner M. , Reiprich S. :Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes Development 141 2014 ), S. 39-50 ISSN: 1477-9129 10.1242/dev.098418 May VEL. , Ettle B. , Pöhler AM. , Nuber S. , Ubhi K. , Rockenstein E. , Winner B. , Wegner M. , Masliah E. , Winkler J. :?-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy Neurobiology of Aging 35 2014 ), S. 2357-68 ISSN: 0197-4580 10.1016/j.neurobiolaging.2014.02.028 Paul M. , Harvey RP. , Wegner M. , Sock E. :Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types Cellular and Molecular Life Sciences 71 2014 ), S. 2931-45 ISSN: 1420-682X 10.1007/s00018-013-1523-x Reiprich S. , Wegner M. :Sox2: A multitasking networker. Neurogenesis 2014 ), S. e962391 ISSN: 2326-2133 Mao Y.Y., Reiprich Simone, Wegner Michael, Fritzsch B.:Targeted deletion of Sox10 by Wnt1-cre defects: neuronal migration and projection in the mouse inner ear. PLoS ONE 2014 ), S. e94580 ISSN: 1932-6203
Glasgow S., Zhu W, Stolt C.C., Huang T.-E., Chen F., LoTurco J.J., Neul J.L., Wegner Michael, Mohila C., Deneen B.:Mutual Antagonism Between Sox10 and NFIA Regulates Diversification of Glial Lineages and Glioma Sub-Types. Nature Neuroscience 2014 ), S. 1322-1329 ISSN: 1097-6256
Winner B. , May VEL. , Ettle B. , Pöhler AM. , Nuber S. , Ubhi K. , Rockenstein E. , Wegner M. , Masliah E. , Winkler J. :α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy. Neurobiology of Aging 35 2014 ), S. 2357-68 ISSN: 0197-4580 10.1016/j.neurobiolaging.2014.02.028 Zhu Q. , Zhao X. , Zheng K. , Li H. , Huang H. , Zhang Z. , Mastracci T. , Wegner M. , Chen Y. , Sussel L. , Qiu M. :Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS Development 141 2014 ), S. 548-55 ISSN: 1477-9129 10.1242/dev.095323
2013
Barraud P. , St John JA. , Stolt C. , Wegner M. , Baker CVH. :Olfactory ensheathing glia are required for embryonic olfactory axon targeting and the migration of gonadotropin-releasing hormone neurons Biology Open 2 2013 ), S. 750-9 ISSN: 2046-6390 10.1242/bio.20135249 Bujalka H. , Koenning M. , Jackson S. , Perreau VM. , Pope B. , Hay CM. , Mitew S. , Hill AF. , Lu QR. , Wegner M. , Srinivasan R. , Svaren J. , Willingham M. , Barres BA. , Emery B. :MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes Plos Biology 11 2013 ), S. e1001625 ISSN: 1544-9173 10.1371/journal.pbio.1001625 Harris ML. , Buac K. , Shakhova O. , Hakami RM. , Wegner M. , Sommer L. , Pavan WJ. :A dual role for SOX10 in the maintenance of the postnatal melanocyte lineage and the differentiation of melanocyte stem cell progenitors PLoS Genetics 9 2013 ), S. e1003644 ISSN: 1553-7390 10.1371/journal.pgen.1003644 Hornig J. , Fröb F. , Vogl M. , Hermans-Borgmeyer I. , Tamm ER. , Wegner M. :The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes PLoS Genetics 9 2013 ), S. e1003907 ISSN: 1553-7390 10.1371/journal.pgen.1003907 Usui A., Mochizuki Y., Iida A., Miyauchi E., Satoh S., Sock Elisabeth, Nakauchi H., Aburatani H., Murakami A., Wegner Michael, Watanabe S.:The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells. Development 2013 ), S. 740-750 ISSN: 1477-9129 10.1242/dev.090274
Trost A. , Schroedl F. , Lange S. , Rivera FJ. , Tempfer H. , Korntner S. , Stolt C. , Wegner M. , Bogner B. , Kaser-Eichberger A. , Krefft K. , Runge C. , Aigner L. , Reitsamer HA. :Neural crest origin of retinal and choroidal pericytes Investigative Ophthalmology & Visual Science 54 2013 ), S. 7910-21 ISSN: 0146-0404 10.1167/iovs.13-12946 Vogl M. , Reiprich S. , Küspert M. , Kosian T. , Schrewe H. , Nave KA. , Wegner M. :Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia The Journal of Neuroscience 33 2013 ), S. 6679-90 ISSN: 1529-2401 10.1523/JNEUROSCI.5178-12.2013 Usui A., Iwagawa T., Mochizuki Y., Iida A., Wegner Michael, Murakami A., Watanabe S.:Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development. Febs Letters 2013 ), S. 358-363 ISSN: 0014-5793 10.1016/j.febslet.2012.12.017
Wegner M. :Mighty bugs: leprosy bacteria turn schwann cells into stem cells. Cell 2013 ), S. 15-16 ISSN: 0092-8674 10.1016/j.cell.2013.01.001 Doddrell R.D., Dun X.P., Shivane A., Feltri M.L., Wrabetz L., Wegner Michael, Sock Elisabeth, Hanemann C.O., Parkinson D.B.:Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells. Brain 2013 ), S. 549-563 ISSN: 0006-8950 10.1093/brain/aws353
Weider M. , Reiprich S. , Wegner M. :Sox appeal - Sox10 attracts epigenetic and transcriptional regulators in myelinating glia Biological Chemistry 394 2013 ), S. 1583-93 ISSN: 1431-6730 10.1515/hsz-2013-0146
2012
Fröb Franziska, Bremer M., Finzsch M., Kichko Tetyana, Reeh Peter W., Tamm E.R., Charnay P., Wegner Michael:Establishment of myelinating Schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox10. Glia 2012 ), S. 806-819 ISSN: 0894-1491 10.1002/glia.22310
Küspert Melanie, Weider Matthias, Müller Jana, Hermans-Borgmeyer I., Meijer D., Wegner Michael:Desert Hedgehog links transcription factor Sox10 to perineurial development. Journal of Neuroscience 2012 ), S. 5472-5480 ISSN: 0270-6474 10.1523/jneurosci.5759-11.2012
Wahlbuhl M., Reiprich Simone, Vogl M.R., Bösl M.R., Wegner Michael:Transcription factor Sox10 orchestrates activity of a neural crest-specific enhancer in the vicinity of its gene. Nucleic Acids Research 2012 ), S. 88-101 ISSN: 0305-1048 10.1093/nar/gkr734
Shakhova O., Zingg D., Schaefer S.M., Hari L., Civenni G., Blunschi J., Claudinot S., Okoniewski M., Beermann F., Mihic-Probst D., Moch H., Wegner Michael, Dummer R., Barrandon Y., Cinelli P., Sommer L.:Sox10 promotes the formation and maintenance of giant congenital nevus and melanoma. Nature Cell Biology 2012 ), S. 882-890 ISSN: 1465-7392
Yusuf D., Butland S.I., Swanson M.I., Bolotin E., Ticoll A., Cheung W.A., Zhang X.Y., Dickman C.T., Fulton D.L., Lim J.S., Schnabl J.M., Ramos O.H., Vasseur-Cognet M., de Leeuw C.N., Simpson E.M., Ryffel G.U., Lam E.W., Kist R., Wilson M.S., Marco-Ferreres R., Brosens J.J., Beccari L.L., Bovolenta P., Benayoun B.A., Monteiro L.J., Schwenen H.D., Grontved L., Wederell E., Mandrup S., Veitia R.A., Chakravarthy H., Hoodless P.A., Mancarelli M., Torbett B.E., Banham A.H., Reddy S.P., Cullum R.L., Liedtke M., Tschan M.P., Vaz M., Rizzino A., Zannini M., Frietze S., Farnham P.J., Eijkelenboom A., Brown P.J., Laperriere D., Leprince D., de Cristofaro T., Prince K.L., Putker M., Del Peso L., Camenich G., Wenger R.H., Mikula M., Rozendaal M., Mader S., Ostrowski J., Rhodes S.J., Van Rechem C., Boulay G., Olechnowicz S.W., Breslin M.B., Lan M.S., Nanan K.K., Wegner Michael, Hou J., Mullen R.D., Colvin S.C., Noy P.J., Webb C.F., Witek M.E., Ferrell S., Daniel J.M., Park J., Waldman S.A., Peet D.J., Taggart M., Jayaraman P.S., Karrich J.J., Blom B., Vesuna F., O´Green H., Sun Y., Gronostajski R.M., Woodcroft M.W., Hough M.R., Chen E., Europe-Finner N., Karolczak-Bayatti M., Bailey J., Hankinson O., Raman V., Lebrun D.P., Biswal S., Harvey C.J., Debruyne J.P., Hogenesch J.B., Hevner R.F., Heligon C., Luo X.M., Blank M.C., Millen K.J., Sharlin D.S., Forrest D., Dahlman-Wright K., Zhao C., Mishima Y., Sinha S., Chakrabarti R., Portales-Casamar E., Sladek F.M., Bradley P.H., Wasserman W.W.:The Transcription Factor Encyclopedia. Genome Biology 2012 ), S. R24 ISSN: 1474-7596 10.1186/gb-2012-13-3-r24
Mu L., Berti L., Masserdotti G., Covic M., Michaelidis T., Doberauer K., Merz K., Rehfeld F., Haslinger A., Wegner Michael, Sock Elisabeth, Lefebvre V., Couillard-Depres S., Aigner L., Berninger B., Lie Dieter Chichung:SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis. Journal of Neuroscience 2012 ), S. 3067-3080 ISSN: 0270-6474 10.1523/JNEUROSCI.4679-11.2012
Weider Matthias, Küspert Melanie, Bischof Melanie, Vogl M.R., Hornig Julia, Loy Kristina, Kosian T., Müller Jana, Hillgärtner Simone, Tamm E.R., Metzger D. , Wegner Michael:Chromatin remodelling factor Brg1 is required for Schwann cell differentiation and myelination. Developmental Cell 2012 ), S. 193-201 ISSN: 1534-5807 10.1016/j.devcel.2012.05.017
2011
Bremer M., Fröb Franziska, Kichko Tetyana, Reeh Peter W., Tamm E.R., Suter U., Wegner Michael:Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve. Glia 2011 ), S. 1022-1032 ISSN: 0894-1491 10.1002/glia.21173
Küspert M. , Hammer A. , Bösl M. , Wegner M. :Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer. Nucleic Acids Research 2011 ), S. 1280-1293 ISSN: 0305-1048 10.1093/nar/gkq951 Lin L., Lee V.M., Wang Y., Lin J.S., Sock Elisabeth, Wegner Michael, Lei L.:Sox11 regulates survival and axonal growth of embryonic sensory neurons. Developmental Dynamics 2011 ), S. 52-64 ISSN: 1058-8388 10.1002/dvdy.22489
Reginensi A., Clarkson M., Neirijnck Y., Lu B., Ohyama T., Groves A.K., Sock Elisabeth, Wegner Michael, Costantini F., Chaboissier M.C., Schedl A.:SOX9 controls epithelial branching by activating RET effector genes during kidney development. Human Molecular Genetics 2011 ), S. 1143-1153 ISSN: 0964-6906 10.1093/hmg/ddq558
Gallenberger M., Meinel D., Kroeber M., Wegner Michael, Milkereit P., Bösl M.R., Tamm E.R.:Lack of Wdr36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro. Human Molecular Genetics 2011 ), S. 422-435 ISSN: 0964-6906 10.1093/hmg/ddq478
Wegner M. :SOX after SOX: SOXession regulates neurogenesis. Genes & Development 2011 ), S. 2423-24-28 ISSN: 0890-9369 10.1101/gad.181487.111 John N., Cinelli P., Wegner Michael, Sommer L.:Transforming Growth Factor β-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells. Stem cells 2011 ), S. 689-699 ISSN: 0250-6793 10.1002/stem.607
2010
Thein D.C., Thalhammer J.M., Hartwig Anna, Crenshaw III E.B., Lefebvre V., Wegner Michael, Sock Elisabeth:The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development. Journal of neurochemistry 2010 ), S. 131-141 ISSN: 1471-4159 10.1111/j.1471-4159.2010.06910.x
Cossais Francois, Wahlbuhl Mandy, Müller Jana, Wegner Michael:SOX10 structure function analysis in the chicken reveals important insights into its role in human neurocristopathies. Human Molecular Genetics 2010 ), S. 2409-2420 ISSN: 0964-6906
Reiprich Simone, Müller Jana, Schreiner S., Wegner Michael:Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells. Journal of Neurochemistry 2010 ), S. 744-754 ISSN: 0022-3042 10.1111/j.1471-4159.2009.06498.x
Guth S.I.E., Bösl M.R., Sock Elisabeth, Wegner Michael:Evolutionary conserved sequence elements with embryonic enhancer activity in the vicinity of the mammalian Sox8 gene. International Journal of Biochemistry & Cell Biology 2010 ), S. 465-471 ISSN: 1357-2725 10.1016/j.biocel.2009.07.008
Bhattaram P., Penzo-Mendez A., Sock Elisabeth, Colmenares C., Kaneko K.J., Vassilev A., DePamphilis M.L., Wegner Michael, Lefebvre V.:Organogenesis relies on Sox4, Sox11, and Sox12 for survival of neural and mesenchymal progenitor cells. Nature Communications 2010 ), S. 9 ISSN: 2041-1723
Cossais Francois, Sock Elisabeth, Hornig J., Schreiner S., Kellerer S., Bösl M.R., Russel S., Wegner Michael:Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression. Developmental Biology 2010 ), S. 267-281 ISSN: 0012-1606 10.1016/j.ydbio.2010.01.038
Breuskin I., Bodson M., Thelen N., Thiry M., Borgs L., Nguyen L., Stolt Claus, Wegner Michael, Lefebvre P.P., Malgrange B.:Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10. Journal of Neurochemistry 2010 ), S. 1827-1839 ISSN: 0022-3042 10.1111/j.1471-4159.2010.06897.x
Stolt C. , Wegner M. :SoxE function in vertebrate nervous system development. International Journal of Biochemistry & Cell Biology 2010 ), S. 437-440 ISSN: 1357-2725 10.1016/j.biocel.2009.07.014 Wegner M. :All purpose SOX: The many roles of Sox proteins in gene expression. International Journal of Biochemistry & Cell Biology 2010 ), S. 381-390 ISSN: 1357-2725 10.1016/j.biocel.2009.07.006 Staffler A., Hammel M., Wahlbuhl Mandy, Bidlingmaier C., Flemmer A.W., Pagel P., Nicolai T., Wegner Michael, Holzinger A.:Heterozygous SOX9 mutations allowing for residual DNA-binding and transcriptional activation lead to the acampomelic variant of Campomelic Dysplasia. Human Mutation 2010 ), S. E1436-1444 ISSN: 1059-7794 10.1002/humu.21238
Kanykina N., Abelson K., King D., Liakhovitskaia A., Schreiner S., Wegner Michael, Kozlova E.N.:In vitro and in vivo effects on neural crest stem cell differentiation by conditional activation of Runx1 short isoform and its effect on neuropathic pain behaviour. Upsala Journal of Medical Sciences 2010 ), S. 56-64 ISSN: 0300-9734 10.3109/03009730903572065
Wallace A., Schmidt C., Schachner M., Wegner Michael, Anderson R.:L1cam acts as a modifier gene during enteric nervous system development. Neurobiology of Disease 2010 ), S. 622-633 ISSN: 0969-9961 10.1016/j.nbd.2010.08.006
Park J., Zhang J.J.R., Moro A., Kushida M., Wegner Michael, Kim P.C.W.:Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage. Developmental Dynamics 2010 ), S. 514-526 ISSN: 1058-8388 10.1002/dvdy.22192
Finzsch M., Schreiner S., Kichko T., Reeh R., Tamm E.R., Bösl M.R., Meijer D., Wegner Michael:Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. The Journal of Cell Biology 2010 ), S. 701-712 ISSN: 0021-9525 10.1083/jcb.200912142
Potzner M.R., Tsarovina K., Binder E., Penzo-Méndez A., Lefebvre V., Rohrer H., Wegner Michael, Sock Elisabeth:Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system. Development 2010 ), S. 775-784 ISSN: 1477-9129 10.1242/dev.042101
2009
Wolf M., Lommes P., Sock Elisabeth, Reiprich Simone, Friedrich R.P., Müller Jana, Stolt Claus, Bermingham J.R., Wegner Michael:Replacement of related POU transcription factors leads to severe defects in mouse forebrain development. Developmental Biology 2009 ), S. 418-428 ISSN: 0012-1606 10.1016/j.ydbio.2009.06.011
Guth S.I.E., Schmidt K., Hess A., Wegner Michael:Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor. Journal of Lipid Research 2009 ), S. 1269-1280 ISSN: 0022-2275 10.1194/jlr.M800531-JLR200
Aldskogius H., Berens C., Kanaykina N., Liakhovitskaia A., Medvinsky A., Sandelin M., Schreiner S., Wegner Michael, Hjerling-Leffler J., Kozlova E.N.:Regulation of Boundary Cap Neural Crest Stem Cell Differentiation after Transplantation. Stem cells 2009 ), S. 1592-1603 ISSN: 0250-6793 10.1002/stem.77
Barrionuevo F., Georg I., Scherthan H., Lécureuil C., Guillou F., Wegner Michael, Scherer G.:Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8. Developmental Biology 2009 ), S. 301-312 ISSN: 0012-1606 10.1016/j.ydbio.2008.12.011
Batista-Brito R., Rossignol E., Hjerling-Leffler J., Denaxa M., Wegner Michael, Lefebvre V., Pachnis V., Fishell G.:The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron 2009 ), S. 466-481 ISSN: 0896-6273 10.1016/j.neuron.2009.08.005
2008
Reiprich Simone, Stolt Claus, Schreiner S., Parlato R., Wegner Michael:SoxE proteins are differentially required in mouse adrenal gland development. Molecular Biology of the Cell 2008 ), S. 1575-1586 ISSN: 1059-1524 10.1091/mbc.E07-08-0782
Wurm A., Sock Elisabeth, Fuchshofer R., Wegner Michael, Tamm E.R.:Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11. Experimental Eye Research 2008 ), S. 895-907 ISSN: 0014-4835 10.1016/j.exer.2008.03.004
Stolt Claus, Lommes P., Hillgärtner Simone, Wegner Michael:The transcription factor Sox5 modulates Sox10 function during melanocyte development. Nucleic Acids Research 2008 ), S. 5427-5440 ISSN: 0305-1048 10.1093/nar/gkn527
Müller S.M., Stolt Claus, Terszowski G., Blum C., Amagai T., Kessaris N., Iannarelli P., Richardson W.D., Wegner Michael, Rodewald H.R.:Neural crest origin of perivascular mesenchyme in the adult thymus. Journal of Immunology 2008 ), S. 5344-5351 ISSN: 0022-1767
Finzsch Markus, Stolt Claus, Lommes P., Wegner Michael:Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression. Development 2008 ), S. 637-646 ISSN: 1477-9129 10.1242/dev.010454
Wegner M. :A matter of identity: transcriptional control in oligodendrocytes. Journal of Molecular Neuroscience 2008 ), S. 3-12 ISSN: 0895-8696 Aquino J.B., Marmigere F., Lallemend F., Lundgren T.K., Villar M.J., Wegner Michael, Ernfors P.:Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues. Gene Expression Patterns 2008 ), S. 217-226 ISSN: 1567-133X 10.1016/j.gep.2008.01.001
Guth S.I.E., Wegner Michael:Having it both ways: Sox protein function between conservation and innovation. Cellular and Molecular Life Sciences 2008 ), S. 3000-3018 ISSN: 1420-682X 10.1007/s00018-008-8138-7
Hoff S., Zeller F., Hann von Weyern C.W., Wegner Michael, Schemann M., Michel K., Rühl A.:Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. Journal of Comparative Neurology 2008 ), S. 356-371 ISSN: 0021-9967 10.1002/cne.21769
Wang H., Leav I., Ibaragi S., Wegner Michael, Hu G.F., Lu M., Balk S., Yuan X.:SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion. Cancer Research 2008 ), S. 1625-1630 ISSN: 0008-5472 10.1158/0008-5472.CAN-07-5915
Hoser M., Potzner M.R., Koch J.M.C., Bösl M.R., Wegner Michael, Sock Elisabeth:Sox12 deletion in the mouse reveals non-reciprocal redundancy with the related Sox4 and Sox11 transcription factors. 2008 ), S. 4675-4687
2007
Hoser M. , Baader S.L., Bösl M.R., Ihmer A., Wegner Michael, Sock Elisabeth:Prolonged glial expression of Sox4 in the central nervous system leads to architectural cerebellar defects and ataxia. The Journal of Neuroscience 2007 ), S. 5495-5505 ISSN: 1529-2401
Schlierf B., Friedrich R.P., Felsberg J., Reifenberger G., Wegner Michael:Expression of SoxE and SoxD genes in human gliomas. Neuropathology and Applied Neurobiology 2007 ), S. 621-630 ISSN: 0305-1846 10.1111/j.1365-2990.2007.00881.x
Liu Z., Hu X., Cai J., Liu B., Peng X., Wegner Michael, Qiu M.:Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms. Developmental Biology 2007 ), S. 683-693 ISSN: 0012-1606 10.1016/j.ydbio.2006.10.007
Werner T., Hammer A., Wahlbuhl Mandy, Bösl Michael, Wegner Michael:Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis. Nucleic Acids Research 2007 ), S. 6526-6538 ISSN: 0305-1048 10.1093/nar/gkm727
Inoue K., Ohyama T., Sakuragi Y., Li-Hua Y., Yamamoto R., Yu L.-H., Goto Y-i., Wegner Michael, Lupski J.R.:Translation of SOX10 3' untranslated region causes a complex severe neurocristopathy by generation of a deleterious functional domain. Human Molecular Genetics 2007 ), S. 3037-3046 ISSN: 0964-6906 10.1093/hmg/ddm262
Schreiner S., Cossais Francois, Fischer K., Scholz S., Bösl Rebecca, Holtmann B., Sendtner M., Wegner Michael:Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development 2007 ), S. 3271-3281 ISSN: 1477-9129 10.1242/dev.003350
2006
Stolt Claus, Schlierf A., Lommes Petra, Hillgärtner S., Werner T., Kosian T., Sock Elisabeth, Kessaris N., Richardson W.D., Lefebre V., Wegner Michael:SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Developmental Cell 2006 ), S. 697-709 ISSN: 1534-5807 10.1016/j.devcel.2006.08.011
Kessaris N., Fogarty M., Iannarelli P., Grist M., Wegner Michael, Richardson W.D.:Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an early embryonic lineage. Nature Neuroscience 2006 ), S. 173-179 ISSN: 1097-6256
Ito Y., Wiese S., Chittka A., Rossol W., Bömmel H., Watabe K., Wegner Michael, Sendtner M.:Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells. Proceedings of the National Academy of Sciences of the United States of America 2006 ), S. 7871-7876 ISSN: 0027-8424 10.1073/pnas.0602332103
Wißmüller S., Kosian T., Wolf Matthias, Wegner Michael:The High-mobility-group domain of Sox proteins interacts with the DNA-binding domains of many transcription factors. Nucleic Acids Research 2006 ), S. 1735-1744 ISSN: 0305-1048 10.1093/nar/gkl105
Marmigere F., Montelius A., Wegner Michael, Groner Y., Reichardt L.F., Ernfors P.:The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons. Nature Neuroscience 2006 ), S. 180-187 ISSN: 1097-6256 10.1038/nn1631
Schlierf Beate, Werner T., Glaser Gabriele, Wegner Michael:Expression of Connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor. Journal of Molecular Biology 2006 ), S. 11-21 ISSN: 0022-2836 10.1016/j.jmb.2006.05.072
Bannykh S.I., Stolt Claus, Kim J., Perry A., Wegner Michael:Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas. Journal of Neuro-Oncology 2006 ), S. 115-127 ISSN: 0167-594X
Kellerer S., Schreiner Silke, Stolt Claus, Scholz Sebastian, Bösl M.R., Wegner Michael:Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development 2006 ), S. 2875-286 ISSN: 1477-9129 10.1242/dev.02477
2005
Schmidt K., Schinke T., Haberland M., Priemel M., Schilling A.F., Mueldner C., Rueger J.M., Sock Elisabeth, Wegner Michael, Amling M.:The high-mobility-group transcription factor Sox8 is a negative regulator of osteoblast differentiation. The Journal of Cell Biology 2005 ), S. 899-910 ISSN: 0021-9525 10.1083/jcb.200408013
Baranek C., Sock Elisabeth, Wegner Michael:The POU protein Oct-6 is a nucleocytoplasmic shuttling protein. Nucleic Acids Research 2005 ), S. 6277-6286 ISSN: 0305-1048 10.1093/nar/gki947
Stolt Claus, Schmitt S., Lommes Petra, Sock Elisabeth, Wegner Michael:Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord. Developmental Biology 2005 ), S. 309-317 ISSN: 0012-1606 10.1016/j.ydbio.2005.03.010
Wegner M. :Secrets to a healthy Sox life: Lessons for melanocytes. Pigment Cell Research 2005 ), S. 74-85 ISSN: 0893-5785 10.1111/j.1600-0749.2005.00218.x Friedrich R.P., Schlierf Beate, Tamm E.R., Bösl M.R., Wegner Michael:The class III POU domain protein Brn-1 can fully replace the related Oct-6 during Schwann cell development and myelination. Molecular and Cellular Biology 2005 ), S. 1821-1829 ISSN: 0270-7306 10.1128/MCB.25.5.1821-1829.2005
Schlierf Beate, Lang Stefan, Kosian T., Werner Thomas, Wegner Michael:The high-mobility group transcription factor Sox10 interacts with the N-myc interacting protein Nmi. Journal of Molecular Biology 2005 ), S. 1033-1042 ISSN: 0022-2836 10.1016/j.jmb.2005.09.013
Thomee C., Schubert S.W., Parma J., Le P.Q., Hashemolhosseini Said, Wegner Michael, Abramowicz M.J.:GCMB mutation in familial isolated hypo-parathyroidism with residual secretion of parathyroid hormone. Journal of Clinical Endocrinology and Metabolism 2005 ), S. 2487-2492 ISSN: 0021-972X
Wegner M. , Stolt C. :From stem cells to neurons and glia: a soxist's view of neural development. Trends in Neurosciences 2005 ), S. 583-588 ISSN: 0166-2236 10.1016/j.tins.2005.08.008 Maka Marzena, Stolt Claus, Wegner Michael:Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect. Developmental Biology 2005 ), S. 155-169 ISSN: 0012-1606 10.1016/j.ydbio.2004.09.014
2004
Sock Elisabeth, Rettig S.D., Enderich J., Bösl M.R., Tamm E.R., Wegner Michael:Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Molecular and Cellular Biology 2004 ), S. 6635-6644 ISSN: 0270-7306 10.1128/MCB.24.15.6635-6644.2004
Ludwig Andreas, Schlierf Beate, Schardt A., Nave K.A., Wegner Michael:A Sox10 rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes. Genesis 2004 ), S. 171-175 ISSN: 1526-954X
Chaboissier M.-C., Kobayashi A., Vidal V.I.P., Lützkendorf S., van de Kant H.J.G., Wegner Michael, de Rooij D.G., Behringer R.R., Schedl A.:Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 2004 ), S. 1891-1901 ISSN: 1477-9129 10.1242/dev.01087
Schubert S.W., Kardash E., Khan M.A., Cheusova T., Kilian K., Wegner Michael:Interaction, Cooperative Promoter Modulation and Renal Colocalisation of GCMa and Pitx2. Journal of Biological Chemistry 2004 ), S. 50358-50365 ISSN: 0021-9258
Ludwig A., Rehberg S., Wegner Michael:Melanocyte-Specific Expression Of Dopachrome Tautomerase Is Dependent On Synergistic Gene Activation By The Sox10 And Mitf Transcription Factors. Febs Letters 2004 ), S. 236-244 ISSN: 0014-5793 10.1016/S0014-5793(03)01446-7
Inoue K., Khajavi M., Ohyama T., Hirabayashi S.-I., Wilson J., Reggin J.D., Mancias P., Butler I.J., Wilkinson M.F., Wegner Michael, Lupski J.R.:Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nature Genetics 2004 ), S. 361-369 ISSN: 1061-4036 10.1038/ng1322
Hashemolhosseini Said, Schmidt K., Kilian K., Rodriguez E., Wegner Michael:Conservation and variation of structure and function in a newly identified GCM homolog from chicken Journal of Molecular Biology 2004 ), S. 441-451 ISSN: 0022-2836 10.1016/j.jmb.2003.12.029
Wegner M. , Hashemolhosseini S. :Impacts of a new trancription factor family: Mammalian GCM proteins in health and disease. The Journal of Cell Biology 2004 ), S. 765-768 ISSN: 0021-9525 Stolt Claus, Lommes Petra, Friedrich R.P., Wegner Michael:Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy. Development 2004 ), S. 2349-2358 ISSN: 1477-9129 10.1242/dev.01114
2003
Sock Elisabeth, Pagon Roberta A., Keymolen Kathelijn, Lissens Willy, Wegner Michael, Scherer Gerd:Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia Human Molecular Genetics 12 2003 ), S. 1439-1447 ISSN: 0964-6906
Stolt Claus, Lommes Petra, Sock Elisabeth, Chaboissier M.-C., Schedl A., Wegner Michael:The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes & Development 2003 ), S. 1677-1689 ISSN: 0890-9369 10.1101/gad.259003
Huber W.E., Price R., Widlund H.R., Du J., Davis I.J., Wegner Michael, Fisher D.E.:A tissue restricted cAMP transcriptional response: SOX10 modulates MSH-triggered expression of MITF in melanocytes. Journal of Biological Chemistry 2003 ), S. 45224-45230 ISSN: 0021-9258
Lioubinski O, Müller M, Wegner Michael, Sander Manfred:Expression of Sox transcription factors in the developing mouse pancreas. Developmental Dynamics 2003 ), S. 402-408 ISSN: 1058-8388 10.1002/dvdy.10311
Schmidt Katy, Glaser Gabriele, Wernig Anton, Wegner Michael, Rosorius Olaf:Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis Journal of Biological Chemistry 2003 ), S. 29769-29775 ISSN: 0021-9258 10.1074/jbc.M301539200
Cohen Serge X., Moulin Martine, Hashemolhosseini Said, Kilian Karin, Wegner Michael, Müller Christoph W.:Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition EMBO Journal 22 2003 ), S. 1835-45 ISSN: 0261-4189 10.1093/emboj/cdg182
2002
Hashemolhosseini S. , Hadjihannas M. , Haase C. , Amann KU. , Wegner M. :Restricted expression of mGCMa in kidney ind thymus Mechanisms of Development 2002 ), S. in press ISSN: 0925-4773 Hashemolhosseini Said, Hadjihannas Michel, Stolt Claus, Haas Christian, Amann Kerstin U., Wegner Michael:Restricted expression of mouse GCMa/Gcm1 in kidney and thymus Mechanisms of Development 118 2002 ), S. 175-178 ISSN: 0925-4773 10.1016/S0925-4773(02)00239-3
Schlierf Beate, Ludwig Andreas, Klenovsek Karin, Wegner Michael:Cooperative binding of Sox10 to DNA: requirements and consequences Nucleic Acids Research 30 2002 ), S. 5509-5516 ISSN: 0305-1048 10.1093/nar/gkf690
Cohen Serge X., Moulin Martine, Schilling Oliver, Meyer-Klaucke Wolfram, Schreiber Jörg, Wegner Michael, Müller Christoph W.:The GCM domain is a Zn-coordinating DNA-binding domain Febs Letters 528 2002 ), S. 95-100 ISSN: 0014-5793 10.1016/S0014-5793(02)03257-X
Rehberg Stephan, Lischka Peter, Glaser Gabriele, Stamminger Thomas, Wegner Michael, Rosorius Olaf:Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation Molecular and Cellular Biology 22 2002 ), S. 5826-5834 ISSN: 0270-7306 10.1128/MCB.22.16.5826-5834.2002
Stolt Claus, Rehberg Stephan, Ader Marius, Lommes Petra, Riethmacher Dieter, Schachner Melitta, Bartsch Udo, Wegner Michael:Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10 Genes & Development 16 2002 ), S. 165-170 ISSN: 0890-9369 10.1101/gad.215802
2001
Sock Elisabeth, Schmidt Katy, Hermanns-Borgmeyer Irm, Bösl Michael, Wegner Michael:Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8 Molecular and Cellular Biology 21 2001 ), S. 6951-6959 ISSN: 0270-7306 10.1128/MCB.21.20.6951-6959.2001
Wegner Michael, Riethmacher Dieter:Chronicles of a switch hunt: gcm genes in development Trends in Genetics 17 2001 ), S. 286-90 ISSN: 0168-9525 10.1016/S0168-9525(01)02275-2
Wegner M. :Expression of transcription factors during oligodendroglial development Microscopy Research and Technique 52 2001 ), S. 746-752 ISSN: 1059-910X 10.1002/jemt.1059 Paratore Christian, Goerich Derk E., Suter Ueli, Wegner Michael, Sommer Lukas:Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling Development 128 2001 ), S. 3949-3961 ISSN: 1477-9129
Britsch Stefan, Goerich Derk, Riethmacher Dieter, Peirano Reto, Rossner Moritz, Nave Klaus-Armin, Birchmeier Carmen, Wegner Michael:The transcription factor Sox10 is a key regulator of peripheral glial development Genes & Development 15 2001 ), S. 66-78 ISSN: 0890-9369 10.1101/gad.186601
Sonnenberg-Riethmacher Eva, Miehe Michaela, Stolt Claus, Goerich Derk, Wegner Michael, Riethmacher Dieter:Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10 Mechanisms of Development 109 2001 ), S. 253-265 ISSN: 0925-4773 10.1016/S0925-4773(01)00547-0
2000
Bondurand Nadège, Pingault Véronique, Goerich Derk, Lemort Nicole, Sock Elisabeth, Le Caignec Cedric, Wegner Michael, Goossens Michel:Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome Human Molecular Genetics 9 2000 ), S. 1907-1917 ISSN: 0964-6906
Baumeister Hans, Wegner Michael, Richter Dietmar, Meyerhof Wolfgang:Dual regulation of somatostatin receptor subtype 1 gene expression by pit-1 in anterior pipuitary GH3 cells Molecular Endocrinology 14 2000 ), S. 255-71 ISSN: 0888-8809
Winklhofer Konstanze, Albrecht Ingrid, Wegner Michael, Heilbronn Regine:Human cytomegalovirus immediate-early gene 2 expression leads to JCV replication in nonpermissive cells via transcriptional activation of JCV T antigen Virology 275 2000 ), S. 323-334 ISSN: 0042-6822 10.1006/viro.2000.0503
Schreiber Jörg, Riethmacher-Sonnenberg Eva, Riethmacher Dieter, Tuerk Elisabeth, Enderich Janna, Bösl Michael, Wegner Michael:Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa Molecular and Cellular Biology 20 2000 ), S. 2466-2474 ISSN: 0270-7306 10.1128/MCB.20.7.2466-2474.2000
Tuerk Elisabeth, Schreiber Jörg, Wegner Michael:Protein stability and domain topology determine the transcriptional activity of the mammalian glial cells missing homolog, GCMb Journal of Biological Chemistry 275 2000 ), S. 4774-82 ISSN: 0021-9258 10.1074/jbc.275.7.4774
Peirano Reto, Goerich Derk, Riethmacher Dieter, Wegner Michael:Protein zero Gene expression is regulated by the glial transcription factor Sox10 Molecular and Cellular Biology 20 2000 ), S. 3198-3209 ISSN: 0270-7306 10.1128/MCB.20.9.3198-3209.2000
Peirano Reto, Wegner Michael:The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences Nucleic Acids Research 28 2000 ), S. 3047-3055 ISSN: 0305-1048
Wegner M. :Transcriptional control in myelinating glia: flavors and spices Glia 31 2000 ), S. 1-14 ISSN: 0894-1491 10.1002/(SICI)1098-1136(200007)31:13.0.CO;2-V Wegner M. :Transcriptional control in myelinating glia: the basic recipe Glia 29 2000 ), S. 118-23 ISSN: 0894-1491 10.1002/(SICI)1098-1136(20000115)29:23.0.CO;2-Q
1999
Sock Elisabeth, Enderich Janna, Wegner Michael:The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP Molecular and Cellular Biology 19 1999 ), S. 2455-2464 ISSN: 0270-7306
Vollgraf Ulrich, Wegner Michael, Richter-Landsberg Christiane:Activation of AP-1 and NF-kappa B transcription factors is involved in hydrogen peroxide-induced apoptopic cell death of oligodendrocytes Journal of Neurochemistry 73 1999 ), S. 2501-2509 ISSN: 0022-3042
Bondurand Nadége, Kuhlbrodt Kirsten, Pingault Véronique, Enderich Janna, Sajus Marc, Tommerup Niels, Warburg Mette, Hennekam Raoul, Read Andrew, Wegner Michael, Goossens Michel:A molecular analysis of the Yemenite deaf-blind hypopigmentation syndrome: Sox10 dysfunction causes different neurocristopathies Human Molecular Genetics 8 1999 ), S. 1785-1789 ISSN: 0964-6906 10.1093/hmg/8.9.1785
Schneider Carolin, Wicht Helmut, Enderich Janna, Wegner Michael, Rohrer Hermann:Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons Neuron 24 1999 ), S. 861-870 ISSN: 0896-6273
Wegner M. :From head to toes: the multiple facets of Sox proteins Nucleic Acids Research 27 1999 ), S. 1409-1420 ISSN: 0305-1048 10.1093/nar/27.6.1409 Reifegerst Rita, Schreiber Jörg, Gülland Sven, Lüdemann Anja, Wegner Michael:mGCMa is a murine transcription factor that overrides cell fate decisions in Drosophila Mechanisms of Development 82 1999 ), S. 141-150 ISSN: 0925-4773 10.1016/S0925-4773(99)00027-1
1998
Kuhlbrodt Kirsten, Herbarth Beate, Sock Elisabeth, Enderich Janna, Hermans-Borgmeyer Irm, Wegner Michael:Cooperative function of POU proteins and SOX proteins in glial cells Journal of Biological Chemistry 273 1998 ), S. 16050-16057 ISSN: 0021-9258 10.1074/jbc.273.26.16050
Kuhlbrodt Kirsten, Schmidt Claudia, Sock Elisabeth, Pingault Veronique, Bondurand Nadege, Goossens Michel, Wegner Michael:Functional analysis of Sox10 mutations found in human Waardenburg-Hirschsprung patients Journal of Biological Chemistry 273 1998 ), S. 23033-23038 ISSN: 0021-9258 10.1074/jbc.273.36.23033
Kuhlbrodt Kirsten, Herbarth Beate, Sock Elisabeth, Hermans-Borgmeyer Irm, Wegner Michael:Sox10, a novel transcriptional modulator in glial cells Journal of Neuroscience 18 1998 ), S. 237-250 ISSN: 0270-6474
Herbarth Beate, Meissner Hildegard, Westphal Manfred, Wegner Michael:Absence of polyomavirus JC in glial brain tumors and glioma-derived cell lines Glia 22 1998 ), S. 415-420 ISSN: 0894-1491 10.1002/(SICI)1098-1136(199804)22:43.0.CO;2-Z
Staib Caroline, Wegner Michael, Grummt Friedrich:Activation of SV40 DNA replication in vivo by amplification-promoting sequences of the mouse ribosomal gene cluster Chromosoma 107 1998 ), S. 33-38 ISSN: 0009-5915
Bondurand Nadege, Kobetz Alexandra, Pingault Veronique, Lemort Nicole, Encha-Razavi Ferechte, Couly Gerard, Goerich Derk, Wegner Michael, Abitbol Marc, Goossens Michel:Expression of Sox10 gene during human development Febs Letters 432 1998 ), S. 168-172 ISSN: 0014-5793 10.1016/S0014-5793(98)00843-6
von der Kammer Heinz, Mayhaus Manuel, Albrecht Claudia, Enderich Janna, Wegner Michael, Nitsch Roger:Muscarinic acetylcholine receptors activate expression of the EGr gene family of transcription factors Journal of Biological Chemistry 273 1998 ), S. 14538-14544 ISSN: 0021-9258 10.1074/jbc.273.23.14538
Nitsch Roger, Rossner Stefan, Albrecht Claudia, Mayhaus Manuel, Enderich Janna, Schliebs Reinhard, Wegner Michael, Arendt Thomas, von der Kammer Heinz:Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter Journal of Physiology-Paris 92 1998 ), S. 257-264 ISSN: 0928-4257 10.1016/S0928-4257(98)80029-6
Herbarth Beate, Pingault Veronique, Bondurand Nadege, Kuhlbrodt Kirsten, Hermans-Borgmeyer Irm, Puliti Aldamaria, Lemort Nicole, Goossens Michel, Wegner Michael:Mutation of the Sry-related Sox10 gene in Dominat megacolon, a mouse model for human Hirschsprung disease Proceedings of the National Academy of Sciences of the United States of America 95 1998 ), S. 5161-5165 ISSN: 0027-8424
Pingault Véronique, Bondurand Nadège, Kuhlbrodt Kirsten, Goerich Derk E., Préhu Marie-Odette, Puliti Aldamaria, Herbarth Beate, Hermans-Borgmeyer Irm, Legius Eric, Matthijs Gert, Amiel Jeanne, Lyonnet Stanislas, Ceccherini Isabella, Romeo Giovanni, Smith Jill Clayton, Read Andrew P., Wegner Michael, Goossens Michel:SOX10 mutations in patients with Waardenburg-Hirschsprung disease Nature Genetics 18 1998 ), S. 171-173 ISSN: 1061-4036 10.1038/ng0298-171
Schreiber Jörg, Enderich Janna, Wegner Michael:Structural requirements for DNA binding of GCM proteins Nucleic Acids Research 26 1998 ), S. 2337-2343 ISSN: 0305-1048 10.1093/nar/26.10.2337
