Sören Turan

Research Interest

SOX11 is a member of the group C SOX transcription factor family and is a critical transcriptional regulator of embryonic and adult neurogenesis. It was shown that heterozygous de novo mutations in SOX11 or deletions of SOX11 cause Coffin-Siris syndrome like syndrome (CSSLS), a rare monogenic disease characterized by hypoplastic nails, microcephaly, and mental retardation. I am interested in developing and testing genetically engineered in vitro models to understand the role of SOX11 in human neurodevelopmental diseases.

Biography

• 2019 Project Leader Bavarian Research Network ForInter
• 2016 Postdoctoral Fellow, FAU Erlangen-Nürnberg
• 2013- 2015 Postdoctoral Fellow, Stanford University
• 2011- 2013 Postdoctoral Fellow, Medical School Hannover
• 2011 Dr. rer. nat, Medical School Hannover
• 2007 Diploma in Biology TU Braunschweig

Publications

Boerstler, T., Wend, H., Krumbiegel, M., Kavyanifar, A., Reis, A., Lie, D. C., Winner,B., Turan, S. (2020). CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome. Stem Cell Research, 101889. doi:10.1016/j.scr.2020.101889
 
Turan,S., Boerstler,T., Kavyanifar,A., Loskarn,S., Reis,A., Winner,B. and Lie,D.C. (2019) A novel human stem cell model for Coffin–Siris syndrome-like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival. Hum. Mol. Genet., 28, 2589–2599.
 
Pozner, T*, Schray, A*, Regensburger, M, Lie, D.C., Schlötzer-Schrehardt, U, Winkler, J, Turan, S., Winner, B. Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci. (2018); 12:914. doi: 10.3389/fnins.2018.00914. *contributed equally
Kavyanifar, A.*, Turan, S.* & Lie, D.C. SoxC transcription factors: multifunctional regulators of neurodevelopment. Cell Tissue Res (2018) 371: 91. http://doi.org/10.1007/s00441-017-2708-7. *contributed equally
 
Turan, S., Farruggio, A. P., Srifa, W., Day, J. W., & Calos, M. P. Precise correction of disease mutations in induced pluripotent stem cells derived from patients with limb girdle muscular dystrophy. Molecular Therapy (2016) 24:4, 685-696
 
Geisinger, J. M., Turan, S., Hernandez, S., Spector, L. P., & Calos, M. P. In Vivo Blunt-End Cloning Through CRISPR / Cas9-Facilitated Non-Homologous end-joining. Nucl. Acids Res., (2016) 44:8,doi:10.1093/nar/gkv1542
 
Mayrhofer, P., Kratzer, B., Sommeregger, W., Steinfellner, W., Reinhart, D., Mader, A., Turan, S. … Kunert, R. Accurate comparison of antibody expression levels by reproducible transgene targeting in engineered recombination-competent CHO cells. Applied Microbiology and Biotechnology (2014), doi:10.1007/s00253-014-6011-1
 
Turan, S., Qiao, J., Madden, S., Benham, C., Kotz, M., Schambach, A., and Bode, J. Expanding Flp-RMCE options: the potential of Recombinase Mediated Twin-Site Targeting (RMTT). Gene. (2014) doi:10.1016/j.gene.2014.06.002
 
Kuehle, J.*, Turan, S.*, Cantz, T., Hoffmann, D., Suerth, J. D., Maetzig, T., … Schambach, A. Modified lentiviral LTRs allow Flp recombinase-mediated cassette exchange and in vivo tracing of “factor-free” induced pluripotent stem cells. Molecular Therapy, (2014) 22:5, 919–28. doi:10.1038/mt.2014.4 *contributed equally
 
Maetzig, T., Kuehle, J., Schwarzer, A., Turan, S., Rothe, M., Chaturvedi, A., … Schambach, A. All-in-One inducible lentiviral vector systems based on drug controlled FLP recombinase. Biomaterials, (2014) 35:14, 4345–56. doi:10.1016/j.biomaterials.2014.01.057
 
Turan, S., Zehe, C., Kuehle, J., Qiao, J., and Bode, J. Recombinase-mediated cassette exchange (RMCE) – a rapidly-expanding toolbox for targeted genomic modifications. Gene, (2013) 515(1), 1–27. doi:10.1016/j.gene.2012.11.016
 
Turan, S., and Bode, J. Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications. FASEB J. (2013) 25:4088-4107; doi:10.1096/fj.11-186940
 
Turan, S., Galla, M., Ernst, E., Qiao, J., Voelkel, C., Schiedlmeier, B., Zehe, C. and Bode, J. Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges, Journal of Molecular Biology, (2011) 407(2):193-221
 
Turan, S., Kuehle, J., Schambach, A., Baum, C., Bode, J. Multiplexing RMCE: Versatile Extensions ofthe Flp-Recombinase-Mediated Cassette-Exchange Technology, Journal of Molecular Biology, (2010) 402:52-69, ISSN 0022-2836