Iris Schäffner

Dr. rer. nat. Iris Schäffner

Institut für Anatomie
Lehrstuhl für Mikroskopische Anatomie und Molekulare Bildgebung

Raum: Raum 02.022
Institut für Biochemie, Fahrstraße 17
91054 Erlangen

 

Research Interest

Regulation of cellular quality control in the adult neurogenic lineage

Neural stem cells generate functional neurons throughout life. My project addresses the role of cellular quality control mechanisms in this process. Specifically, I am investigating how autophagy – a clearance processes critical for maintaining organelle and protein homeostasis – affects stem cell maintenance and neuronal maturation and how autophagy is regulated on the transcriptional level.

Picture website Iris
Adult neural progenitor labeled with a CAG-GFP/Cre and a CAG-mCherry/GFP/LC3 retrovirus to analyze autophagy. Scale bar ≙ 1 µm.

 

 

Biography

2015 – present Postdoctoral Scientist, Institute of Biochemistry, FAU Erlangen
2015 PhD, Technical University Munich, „Fox Transcription factors in adult neurogenesis“
 2009  M.Sc., Molecular Biotechnology, Technical University Munich
 2005  Diploma in Economics, University of Passau

„Description and discussion of precise solutions of Traveling Salesman-Problems with time window restriction“

 

Publications

  • Marschallinger, J, Schäffner, I, Klein, B, Gelfert, R, Rivera, FJ, Illes, S, Grassner, L, Janssen, M, Rotheneichner, P, Schmuckermair, C, Coras, R, Boccazzi, M, Chishty, M, Lagler, FB, Renic, M, Bauer, HC, Singewald, N, Blümcke, I, Bogdahn, U, Couillard-Despres, S, Lie, DC, Abbracchio, MP & Aigner, L (2015): Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nature Communications, 27; 6:8466.
  • Steib, K, Schäffner, I, Ebert, B, Jagasia, R & Lie, DC (2014): Mitochondria modify exercise-induced development of stem cell derived neurons in the adult brain. The Journal of Neuroscience, 34, 6624-6633.
  • Beckervordersandforth, R, Deshpande, A, Schäffner, I, Huttner, HB, Lepier, A, Lie, DC & Götz, M (2014): In vivo targeting of adult neural stem cells in the dentate gyrus by a Split-Cre approach. Stem Cell Reports, 2, 153-162.
  • Ehm, O, Göritz, C, Covic, M, Schäffner, I, Schwarz, TJ, Karaca, E, Kempkes, B, Kremmer, E, Pfrieger, FW, Espinosa, L, Bigas, A, Giachino, C, Taylor, V, Frisén, J & Lie, DC. (2010): RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus. The Journal of Neuroscience, 30, 13794-13807.