Publikationen
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2024
Dorner H. , Stolzer I. , Mattner J. , Kaminski S. , Leistl S. , Edrich LM. , Schwendner R. , Hobauer J. , Sebald A. , Leikam S. , Gonzalez Acera M. , Düll M. , Lang R. , Seidel G. , Seitz T. , Hellerbrand C. , Fuhrmann G. , Distler U. , Tenzer S. , Eichhorn P. , Vieth M. , Schramm C. , Arnold P. , Becker C. , Weidinger C. , Siegmund B. , Atreya R. , Leppkes M. , Naschberger E. , Sampaziotis F. , Dietrich P. , Rauh M. , Wirtz S. , Kremer A. , Neurath M. , Günther C. :Gut Pathobiont–Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis–Associated Inflammatory Bowel Disease Gastroenterology 2024 )ISSN: 0016-5085 10.1053/j.gastro.2024.06.032
2023
Ortiz C. , Klein S. , Reul WH. , Magdaleno F. , Groeschl S. , Dietrich P. , Schierwagen R. , Uschner FE. , Torres S. , Hieber C. , Meier C. , Kraus N. , Tyc O. , Brol M. , Zeuzem S. , Welsch C. , Poglitsch M. , Hellerbrand C. , Alfonso-Prieto M. , Mira F. , Keller UAD. , Tetzner A. , Moore A. , Walther T. , Trebicka J. :Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1 Cell Reports 42 2023 )ISSN: 2211-1247 10.1016/j.celrep.2023.112059 Payani E. , Börner N. , Kolliogiannis D. , Brunner S. , Klein I. , Ehmer U. , Denk G. , Lange CM. , Ograja K. , Dietrich P. , Werner J. , Guba M. :Regional transplant rates depend more on physician-dependent variables than on proximity to transplant center Langenbecks Archives of Surgery 408 2023 ), Art.Nr.: 191 ISSN: 1435-2443 10.1007/s00423-023-02874-9 Sommer J. , Ehnis H. , Seitz T. , Schneider J. , Wild A. , Moceri S. , Buechler C. , Bozec A. , Weber G. , Merkel S. , Beckervordersandforth R. , Steinkasserer A. , Schüle R. , Trebicka J. , Hartmann A. , Boßerhoff AK. , von Hörsten S. , Dietrich P. , Hellerbrand C. :Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity International Journal of Molecular Sciences 24 2023 ), Art.Nr.: 14943 ISSN: 1422-0067 10.3390/ijms241914943
2022
Düll M. , Karlen V. , Vetter M. , Dietrich P. , Kupfer J. , Neurath M. , Kremer A. :Chronic pruritus represents a major burden in non-cholestatic hepatobiliary disorders In: JOURNAL OF HEPATOLOGY , AMSTERDAM 2022 10.1016/s0168-8278(22)00705-x Seitz T. , John N. , Sommer J. , Dietrich P. , Thasler WE. , Hartmann A. , Evert K. , Lang SA. , Boßerhoff AK. , Hellerbrand C. :Role of Fibroblast Growth Factors in the Crosstalk of Hepatic Stellate Cells and Uveal Melanoma Cells in the Liver Metastatic Niche International Journal of Molecular Sciences 23 2022 ), Art.Nr.: 11524 ISSN: 1422-0067 10.3390/ijms231911524 Simon D. , Tascilar K. , Fagni F. , Kleyer A. , Krönke G. , Meder C. , Dietrich P. , Orlemann T. , Mößner J. , Taubmann J. , Mutlu MY. , Knitza J. , Kemenes S. , Liphardt AM. , Schönau V. , Bohr D. , Schuster L. , Minopoulou I. , Leppkes M. , Ramming A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Hueber A. , Manger K. , Manger B. , Atreya R. , Berking C. , Sticherling M. , Neurath M. , Schett G. , Hartmann F. :Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study. The Lancet Rheumatology 4 2022 ), S. e614-e625 ISSN: 2665-9913 10.1016/S2665-9913(22)00191-6 Simon D. , Tascilar K. , Kleyer A. , Fagni F. , Krönke G. , Meder C. , Dietrich P. , Orlemann T. , Kliem T. , Moessner J. , Liphardt AM. , Schoenau V. , Bohr D. , Schuster L. , Hartmann F. , Leppkes M. , Ramming A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Hueber A. , Manger K. , Manger B. , Atreya R. , Berking C. , Sticherling M. , Neurath M. , Schett G. :Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS-CoV-2 in an Unvaccinated Cohort Arthritis and Rheumatology 2022 )ISSN: 2326-5191 10.1002/art.42035 Tascilar K. , Simon D. , Kleyer A. , Fagni F. , Krönke G. , Meder C. , Dietrich P. , Orlemann T. , Kliem T. , Moessner J. , Liphardt AM. , Schönau V. , Bohr D. , Schuster L. , Hartmann F. , Taubmann J. , Leppkes M. , Ramming A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Hueber A. , Manger K. , Manger B. , Atreya R. , Berking C. , Sticherling M. , Neurath M. , Schett G. :LONG-TERM HUMORAL RESPONSE TO SARS-COV-2 VACCINATION IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASE In: ANNALS OF THE RHEUMATIC DISEASES , LONDON 2022 10.1136/annrheumdis-2022-eular.5079
2021
Düll M. , Wolf K. , Vetter M. , Dietrich P. , Neurath M. , Kremer A. :Endogenous Opioid Levels Do Not Correlate With Itch Intensity and Therapeutic Interventions in Hepatic Pruritus Frontiers in Medicine 8 2021 ), Art.Nr.: 641163 ISSN: 2296-858X 10.3389/fmed.2021.641163 Fritz V. , Malek L. , Gaza A. , Wormser L. , Appel M. , Kremer A. , Thasler WE. , Neurath M. , Hellerbrand C. , Boßerhoff AK. , Dietrich P. , Siebler J. :Combined de‐repression of chemoresistance associated mitogen‐activated protein kinase 14 and activating transcription factor 2 by loss of microrna‐622 in hepatocellular carcinoma Cancers 13 2021 ), S. 1-14 ISSN: 2072-6694 10.3390/cancers13051183 Gaza A. , Fritz V. , Malek L. , Wormser L. , Treiber N. , Danner J. , Kremer AE. , Thasler WE. , Siebler J. , Meister G. , Neurath MF. , Hellerbrand C. , Boßerhoff AK. , Dietrich P. :Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11 Neoplasia 23 2021 ), S. 502-514 ISSN: 1522-8002 10.1016/j.neo.2021.04.001 Seitz T. , Hackl C. , Freese K. , Dietrich P. , Mahli A. , Thasler RM. , Thasler WE. , Lang SA. , Boßerhoff AK. , Hellerbrand C. :Xanthohumol, a prenylated chalcone derived from hops, inhibits growth and metastasis of melanoma cells Cancers 13 2021 ), S. 1-12 ISSN: 2072-6694 10.3390/cancers13030511 Vetter M. , Dietrich P. , Kremer A. :Therapy adaption by dose titration of obeticholic acid in a 57-year-old female patient with PBC and advanced liver fibrosis In: SWISS MEDICAL WEEKLY , MUTTENZ 2021 Weindl L. , Atreya I. , Dietrich P. , Neubeck S. , Neurath M. , Pavel ME. :Targeted inhibition of the WEE1 kinase as a novel therapeutic strategy in neuroendocrine neoplasms Endocrine-Related Cancer 28 2021 ), S. 605-620 ISSN: 1351-0088 10.1530/ERC-20-0500
2020
Dietrich P. , Wormser L. , Fritz V. , Seitz T. , de Maria M. , Schambony A. , Kremer A. , Günther C. , Itzel T. , Thasler WE. , Teufel A. , Trebicka J. , Hartmann A. , Neurath M. , von Hörsten S. , Boßerhoff AK. , Hellerbrand C. :Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer Journal of Clinical Investigation 130 2020 ), S. 2509-2526 ISSN: 0021-9738 10.1172/JCI131919 Jefremow A. , Wiesmüller M. , Rouse RA. , Dietrich P. , Kremer A. , Waldner M. , Neurath M. , Siebler J. :Beyond the border: The use of lenvatinib in advanced hepatocellular carcinoma after different treatment lines: A retrospective analysis Journal of Physiology and Pharmacology 71 2020 ), S. 717-728 ISSN: 0867-5910 10.26402/jpp.2020.5.11 Jefremow A. , Wiesmüller M. , Rouse RA. , Dietrich P. , Kremer A. , Waldner M. , Neurath M. , Siebler J. :Efficiency and Toxicity of Lenvatinib in Advanced HCC in Later Treatment Lines In: ONCOLOGY RESEARCH AND TREATMENT , BASEL 2020 Koch A. , Ebert EV. , Seitz T. , Dietrich P. , Berneburg M. , Boßerhoff AK. , Hellerbrand C. :Characterization of glycolysis-related gene expression in malignant melanoma Pathology Research and Practice 216 2020 ), Art.Nr.: 152752 ISSN: 0344-0338 10.1016/j.prp.2019.152752 Linck-Paulus L. , Hellerbrand C. , Boßerhoff AK. , Dietrich P. :Dissimilar Appearances Are Deceptive-Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma Cells 9 2020 )ISSN: 2073-4409 10.3390/cells9010114 Schierwagen R. , Dietrich P. , Klein S. , Uschner FE. , Ortiz C. , Tyc O. , Torres S. , Hellerbrand C. , Sauerbruch T. , Trebicka J. :β-Arrestin2 is increased in liver fibrosis in humans and rodents Proceedings of the National Academy of Sciences of the United States of America 117 2020 ), S. 27082-27084 ISSN: 0027-8424 10.1073/pnas.2014337117 Seitz T. , Freese K. , Dietrich P. , Thasler WE. , Boßerhoff AK. , Hellerbrand C. :Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma Scientific Reports 10 2020 ), Art.Nr.: 4546 ISSN: 2045-2322 10.1038/s41598-020-61510-4 Simon D. , Tascilar K. , Krönke G. , Kleyer A. , Zaiss M. , Heppt F. , Meder C. , Atreya R. , Klenske E. , Dietrich P. , Abdullah A. , Kliem T. , Corte G. , Morf H. , Leppkes M. , Kremer A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Meier C. , Hueber A. , Manger K. , Manger B. , Berking C. , Tenbusch M. , Überla K. , Sticherling M. , Neurath M. , Schett G. , Ramming A. :Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion Nature Communications 11 2020 ), Art.Nr.: 3774 ISSN: 2041-1723 10.1038/s41467-020-17703-6 Simon D. , Tascilar K. , Krönke G. , Kleyer A. , Zaiss M. , Heppt F. , Meder C. , Atreya R. , Klenske E. , Dietrich P. , Abdullah A. , Kliem T. , Corte G. , Morf H. , Leppkes M. , Kremer A. , Ramming A. , Pachowsky M. , Schuch F. , Ronneberger M. , Kleinert S. , Maier C. , Hueber A. , Manger K. , Manger B. , Berking C. , Tenbusch M. , Überla K. , Sticherling M. , Neurath M. , Schett G. :Patients Receiving Cytokine Inhibitors Have Low Prevalence of SARS-CoV-2 Infection In: ARTHRITIS & RHEUMATOLOGY , HOBOKEN 2020
2019
Dietrich P. , Gaza A. , Wormser L. , Fritz V. , Hellerbrand C. , Boßerhoff AK. :Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Is a Novel Prognostic Marker and Contributes to Sorafenib Resistance in Hepatocellular Carcinoma Neoplasia 21 2019 ), S. 257-268 ISSN: 1522-8002 10.1016/j.neo.2018.11.011 Dietrich P. , Hellerbrand C. , Boßerhoff AK. :The delta subunit of rod-specific photoreceptor cgmp phosphodiesterase (Pde6d) contributes to hepatocellular carcinoma progression Cancers 11 2019 ), Art.Nr.: 398 ISSN: 2072-6694 10.3390/cancers11030398 Freese K. , Dietrich P. , Boßerhoff AK. , Hellerbrand C. :Variation of different histone deacetylases and the functional effects of HDAC inhibitors in hepatocellular carcinoma International Liver Congress (Vienna 10. April 2019 - 14. April 2019 )In: JOURNAL OF HEPATOLOGY , AMSTERDAM 2019 10.1016/s0618-8278(19)30712-1 Freese K. , Seitz T. , Dietrich P. , Lee SM. , Thasler WE. , Boßerhoff AK. , Hellerbrand C. :Histone deacetylase expressions in hepatocellular carcinoma and functional effects of histone deacetylase inhibitors on liver cancer cells in vitro Cancers 11 2019 ), Art.Nr.: 1587 ISSN: 2072-6694 10.3390/cancers11101587 Goeppert B. , Truckenmueller F. , Ori A. , Fritz V. , Albrecht T. , Fraas A. , Scherer D. , Silos RG. , Sticht C. , Gretz N. , Mehrabi A. , Bewerunge-Hudler M. , Pusch S. , Bermejo JL. , Dietrich P. , Schirmacher P. , Renner M. , Roessler S. :Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p Scientific Reports 9 2019 )ISSN: 2045-2322 10.1038/s41598-019-40857-3 Mahli A. , Seitz T. , Beckroege T. , Freese K. , Thasler WE. , Benkert M. , Dietrich P. , Weiskirchen R. , Boßerhoff AK. , Hellerbrand C. :Bone Morphogenetic Protein-8B Expression is Induced in Steatotic Hepatocytes and Promotes Hepatic Steatosis and Inflammation In Vitro Cells 8 2019 )ISSN: 2073-4409 10.3390/cells8050457 Stieglitz D. , Lamm S. , Braig S. , Feuerer L. , Kuphal S. , Dietrich P. , Arndt S. , Echtenacher B. , Hellerbrand C. , Karrer S. , Boßerhoff AK. :BMP6-induced modulation of the tumor micro-milieu Oncogene 38 2019 ), S. 609-621 ISSN: 0950-9232 10.1038/s41388-018-0475-x
2018
Riccardo Bertolo, Ithaar Derweesh, Giuseppe Simone, Michele Gallucci, Stephen Ryan, Ahmet Binday, Andrea Minervini, Marco Carini, Andrea Mari, Daniel Eun, Aryeh Keehn, Sisto Perdona, Giuseppe Quarto, James Porter, Michael Liao, Matteo Ferro, Alexandre Mottrie, Geert De Naeyer, Koon Rha, Kidon Chang, Robert Uzzo, Alexander Kutikov, David Chen, Marc Smaldone, Francesco Berardinelli, Luigi Schips, Wesley White, Bo Yang, Chao Zang, Ottavio De Cobelli, Ken Jacobsohn, Peter Langenstroer, Peter Dietrich, Prokar Dasgupta, Ben Challacombe, Nicolo De Luyk, Clayton Lau, Patrick Kilday, Jay Sulek, Chandru Sundaram, Francesco Montorsi, Alessandro Larcher, Umberto Capitanio, Inderbir Gill, Monish Aron, Akbar Ashrafi, Uzoma Anele, Lance Hampton, Gabriele Tuderti, Manuela Costantini, Riccardo Autorino, Francesco Porpiglia:ROBOT-ASSISTED PARTIAL NEPHRECTOMY FOR CT2 RENAL TUMORS: PERIOPERATIVE, FUNCTIONAL AND ONCOLOGICAL OUTCOMES FROM A MULTICENTER ANALYSIS (THE ROSULA PROJECT)
Dietrich P. , Freese K. , Mahli A. , Thasler WE. , Hellerbrand C. , Boßerhoff AK. :Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic "dual-hit" option Oncotarget 9 2018 ), S. 3605-3618 ISSN: 1949-2553 10.18632/oncotarget.23188 Dietrich P. , Kuphal S. , Spruss T. , Hellerbrand C. , Boßerhoff AK. :MicroRNA-622 is a novel mediator of tumorigenicity in melanoma by targeting Kirsten rat sarcoma Pigment Cell & Melanoma Research 2018 )ISSN: 1755-1471 10.1111/pcmr.12698 Schmidt KM. , Dietrich P. , Hackl C. , Guenzle J. , Bronsert P. , Wagner C. , Fichtner-Feigl S. , Schlitt HJ. , Geissler EK. , Hellerbrand C. , Lang SA. :Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis Neoplasia 20 2018 ), S. 1198-1208 ISSN: 1522-8002 10.1016/j.neo.2018.10.001
2017
Dietrich P. , Boßerhoff AK. :Melanoma sponge on pigmentation gene to reduce tumour-suppressive microRNAs Pigment Cell & Melanoma Research 2017 )ISSN: 1755-1471 10.1111/pcmr.12660 Dietrich P. , Koch A. , Fritz V. , Hartmann A. , Boßerhoff AK. , Hellerbrand C. :Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance Gut 2017 )ISSN: 0017-5749 10.1136/gutjnl-2017-315402 Dietrich P. , Kuphal S. , Spruss T. , Hellerbrand C. , Boßerhoff AK. :Wild-type KRAS is a novel therapeutic target for melanoma contributing to primary and acquired resistance to BRAF inhibition Oncogene 2017 )ISSN: 0950-9232 10.1038/onc.2017.391 Mahli A. , Saugspier M. , Koch A. , Sommer J. , Dietrich P. , Lee S. , Thasler R. , Schulze-Luehrmann J. , Lührmann A. , Thasler WE. , Müller M. , Boßerhoff AK. , Hellerbrand C. :ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis Gut 2017 )ISSN: 0017-5749 10.1136/gutjnl-2016-312485
2015
Delic S. , Thuy A. , Schulze M. , Proescholdt MA. , Dietrich P. , Boßerhoff AK. , Riemenschneider MJ. :Systematic Investigation of CMTM Family Genes Suggests Relevance to Glioblastoma Pathogenesis and CMTM1 and CMTM3 as Priority Targets Genes Chromosomes & Cancer 54 2015 ), S. 433-443 ISSN: 1045-2257 10.1002/gcc.22255 Dietrich P. , Boßerhoff AK. :Modifying microRNAs--another piece of the melanoma puzzle Pigment Cell & Melanoma Research 28 2015 ), S. 488-9 ISSN: 1755-1471 10.1111/pcmr.12389 Hartl J. , Dietrich P. , Moleda L. , Mueller-Schilling M. , Wiest R. :Neuropeptide Y restores non-receptor-mediated vasoconstrictive action in superior mesenteric arteries in portal hypertension Liver International 35 2015 ), S. 2556-63 ISSN: 1478-3223 10.1111/liv.12874 Ruedel A. , Dietrich P. , Schubert T. , Hofmeister S. , Hellerbrand C. , Boßerhoff AK. :Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts International Journal of Clinical and Experimental Pathology 8 2015 ), S. 4953-62 ISSN: 1936-2625
